Formulation and Characterization of Gels Containing Natural and Modified Bromelain

Abstract

Background: Bromelain is a complex of plant-derived proteolytic enzymes found in almost all parts of the Pineapple plant (Ananas comosus L.Merr.) and is currently used in treating muscle-skeletal disorders. Objectives: This study aimed to develop natural and modified Bromelain gels for potentially treating muscle-skeletal disorders and assessing their physical-chemical properties. Natural Bromelain and its chemically altered form, modified with dextran aldehyde, were used as active ingredients. Methods: Investigation of physical and chemical properties of gels, identification of gels by Fourier transform infrared (FT-IR) spectroscopy. Results: The proteolytic activity of the gels for 15 months is stable and remains 85-93% compared to the initial activity. Conclusions: The spreadability, consistency, pH, thermal, and colloidal stability of the base and gels containing natural and modified Bromelain were satisfactory.