Phage Therapy for Patients with Bleeding Disorders and Periodontal Diseases

Abstract

Periodontal diseases are frequently associated with bleeding episodes, particularly in patients with hemophilia, wherein the disease manifests as severe bleeding from the gum tissue. Lack of the factor required for proper blood clotting aggravates this condition. Consequently, a vicious cycle ensues: Periodontal diseases precipitate severe bleeding from soft tissues, leading to the formation of pockets in both soft and hard tissues, tooth mobility, and tooth loss. Concurrently, oral hygiene deteriorates, potentially reaching critically low levels or cessation altogether, fostering the accumulation of pathogenic bacteria within the oral cavity and exacerbating the frequency and severity of bleeding episodes. Phage therapy is a promising alternative and non-invasive treatment modality for such patients.