Cotinus Coggygria Polyphenol Extract in Endodontics: Recent Results of Experimental Study

Abstract

Background: Endodontic research has always focused on developing methods or endodontic irrigants to remove the bacteria with minimal side effects. Root Canal Persistent Infection microbiome observation advocated the important role of E. faecalis in secondary infections. Due to the survival mechanism of resistant endo pathogen - Enterococcus feacalis- our research aims to recommend the plant Cotinus coggygria Scop. leaves Polyphenolic Extract (CCPE) solutions as an alternative effective antimicrobial endodontic irrigation solution. At the same time, to achieve successful long-term endodontic outcomes, the fluid chemistry of endodontic irrigants represents the most important challenge. Objectives: The present study aimed to reveal the chemical compatibility of CCPE solution (experimental sample) with the most commonly used irrigants in endodontic practice. Methods: The evaluation was conducted ex vivo and in vitro by immediately visualizing mixtures of different types of endodontic irrigation solutions. Results: Chemical Interaction Observation of experimental CCPE solution suggests that cultivated in Georgia, Cotinus coggygria Scop. polyphenol extract solution is a chemically compatible and safe endodontic irrigant. Conclusions: Identified antibacterial activity, unique formulation rich with tannins, and safe interaction with all types of intercanal solutions allow CCPE to provide a uniform irrigation protocol with optimal disinfection effect and maximal safety margins. The in vivo study is in progress, and this novel herbal/bio preparation is recommended as an alternative antimicrobial endodontic irrigant for effective and safe endodontic irrigant for secondary infection prevention.