Suspected Methadone-Gabapentin Co-Ingestion Associated with Rhabdomyolysis, Acute Kidney Injury, and Peripheral Neuropathy: A Case Report
DOI:
https://doi.org/10.52340/GBMN.2026.01.01.165Keywords:
Acute kidney injury, creatine kinase, gabapentin, hyperkalemia, methadone, rhabdomyolysisAbstract
We report the case of a 27-year-old woman who presented with severe mixed respiratory and metabolic acidosis, rhabdomyolysis characterized by markedly elevated creatine kinase (CK), hyperkalemia, and acute kidney injury following an 18–20-hour period of unconsciousness. Upon admission, the patient reported ingesting an unknown quantity of methadone and gabapentin obtained from non-medical sources; however, no toxicological screening was performed to confirm this. Physical examination revealed hyperemic bullae on the right lower extremity and chest, consistent with prolonged immobilization. Despite aggressive intravenous fluid resuscitation, the patient developed anuria requiring renal replacement therapy. Her hospital course was further complicated by severe hemolytic anemia and urinary tract infection. As acute metabolic disturbances stabilized, a concurrent right sciatic neuropathy was identified, clinically suspected to be a compressive injury secondary to prolonged immobilization.References
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